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endopeptidase substrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Prolyl Endopeptidase (PREP) (2) Bacterial (2) Fluorescent Dye (2) MMP (1) Ser/Thr Protease (1)
By Research Areas:	Cancer (1) Infection (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Targets Recommended: Prolyl Endopeptidase (PREP) Legumain Neprilysin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1670

Z-Gly-Pro-AMC	Fluorescent Dye	Others
Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-amido-4-methylcoumarin (HY-D0027). (λ_ex=380 nm, λ_em=465 nm) .

HY-P4482

Suc-AAPE-pNA

Bacterial Infection

Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity .
HY-P4490

Suc-Ala-Pro-pNA

Prolyl Endopeptidase (PREP) Others

Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .
HY-P4455

Boc-AAG-pNA

Bacterial Infection

Boc-AAG-pNA is a glycine endopeptidase substrate. Boc-AAG-pNA can be used to test the amidase activity glycine endopeptidase .
HY-137220

Z-Gly-Pro-pNA

Prolyl Endopeptidase (PREP) Others

Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity .

Suc-AAPE-pNA	Bacterial	Infection
Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity .

Suc-Ala-Pro-pNA	Prolyl Endopeptidase (PREP)	Others
Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .

Boc-AAG-pNA	Bacterial	Infection
Boc-AAG-pNA is a glycine endopeptidase substrate. Boc-AAG-pNA can be used to test the amidase activity glycine endopeptidase .

Z-Gly-Pro-pNA	Prolyl Endopeptidase (PREP)	Others
Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity .

HY-P3205

Lysyl endopeptidase, Achromobacter sp Lys-C	Others	Others
Lysyl endopeptidase, Achromobacter sp (Lys-C) catalyzes carboxyl oxygen exchange reaction. Lysyl endopeptidase has higher substrate binding affinities and higher catalytic rates at the acidic pHs than at the alkaline pHs .

HY-E70195

α-Lytic protease alphaLP	Ser/Thr Protease	Others
α-Lytic protease (alphaLP) is a serine endopeptidase. α-Lytic protease can cleave substrate at the carboxyl terminal side of alanine, serine, threonine, and valine amino acid residues .

HY-137337

Suc-Ala-Ala-Phe-AMC	Fluorescent Dye	Others
Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2	MMP	Others
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

Z-Gly-Pro-AMC	Chromogenic Substrates
Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-amido-4-methylcoumarin (HY-D0027). (λ_ex=380 nm, λ_em=465 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P4498

Z-Ala-Pro-pNA

Peptides Others

Z-Ala-Pro-pNA is an endopeptidase substrate and can be used to detect the activity of this enzyme .
HY-P4482

Suc-AAPE-pNA

Bacterial Infection

Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity .
HY-P4490

Suc-Ala-Pro-pNA

Prolyl Endopeptidase (PREP) Others

Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .
HY-P4455

Boc-AAG-pNA

Bacterial Infection

Boc-AAG-pNA is a glycine endopeptidase substrate. Boc-AAG-pNA can be used to test the amidase activity glycine endopeptidase .
HY-P4448

Ac-Gly-Pro-AFC

Peptides Others

Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .

Z-Ala-Pro-pNA	Peptides	Others
Z-Ala-Pro-pNA is an endopeptidase substrate and can be used to detect the activity of this enzyme .

Suc-AAPE-pNA	Bacterial	Infection
Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity .

Suc-Ala-Pro-pNA	Prolyl Endopeptidase (PREP)	Others
Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .

Boc-AAG-pNA	Bacterial	Infection
Boc-AAG-pNA is a glycine endopeptidase substrate. Boc-AAG-pNA can be used to test the amidase activity glycine endopeptidase .

Ac-Gly-Pro-AFC	Peptides	Others
Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .

HY-P4516

Z-Phe-Leu-Glu-pNA	Peptides	Cancer
Z-Phe-Leu-Glu-pNA is a chromogenic substrate for glutamyl endopeptidases. Z-Phe-Leu-Glu-pNA has been used as a synthetic substrate in the study of proteolytic enzymes, including trypsin treatment, subtilisin and chymotrypsin. Z-Phe-Leu-Glu-pNA plays an important role in hormone disorders such as prostate cancer and breast cancer .

HY-137337

Suc-Ala-Ala-Phe-AMC	Fluorescent Dye	Others
Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2	MMP	Others
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

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